{"id":202,"date":"2025-03-26T15:19:46","date_gmt":"2025-03-26T15:19:46","guid":{"rendered":"https:\/\/orgchemtr6.org\/?p=202"},"modified":"2025-05-23T10:50:37","modified_gmt":"2025-05-23T10:50:37","slug":"tamio-hayashi","status":"publish","type":"post","link":"https:\/\/orgchemtr6.org\/tr\/tamio-hayashi\/","title":{"rendered":"Tamio Hayashi"},"content":{"rendered":"

Prof.<\/strong>
Department of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan<\/strong><\/p>\n\n\n\n

EDUCATION<\/u><\/strong><\/p>\n\n\n\n

04\/1972\u201303\/1975            Ph D., Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University, Japan (Professor M. Kumada)<\/p>\n\n\n\n

04\/1970\u201303\/1972            Master of Engineering, Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University, Japan<\/p>\n\n\n\n

04\/1966\u201303\/1970            Bachelor of Engineering, Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University, Japan<\/p>\n\n\n\n

PROFESSIONAL EXPERIENCES<\/u><\/strong><\/p>\n\n\n\n

02\/2023\u2013present          Professor (Yushan Scholar), Department of Chemistry, National Taiwan Normal University, Taiwan<\/p>\n\n\n\n

02\/2020\u201301\/2023        Professor (Yushan Scholar), Department of Chemistry, National Tsing Hua University, Taiwan<\/p>\n\n\n\n

05\/2016\u201305\/2019            Professor, Division of Chemistry and Biological Chemistry, School of Physical and                                                                  Mathematical Sciences, Nanyang Technological University, Singapore<\/p>\n\n\n\n

01\/2013\u201305\/2016            Professor, Department of Chemistry, National University of Singapore, Singapore<\/p>\n\n\n\n

04\/2012\u201305\/2016            Principal Scientist II, Institute of Materials Research and Engineering, A*STAR, Singapore<\/p>\n\n\n\n

09\/1994\u201303\/2012            Professor, Department of Chemistry, Graduate School of Science, Kyoto University, Japan<\/p>\n\n\n\n

04\/1989\u201309\/1994            Professor, Catalysis Research Center, Hokkaido University, Japan<\/p>\n\n\n\n

04\/1975\u201303\/1989         Assistant Professor, Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University, Japan<\/p>\n\n\n\n

05\/2011\u201303\/2014         Visiting Professor, King Abdul-Aziz University, Jeddah, Saudi Arabia<\/p>\n\n\n\n

09\/2010\u201305\/2016         Visiting Professor, Hong Kong Baptist University, Hong Kong<\/p>\n\n\n\n

09\/2002\u201308\/2009         Chair Professor of Chirotechnology, Hong Kong Polytechnic University, Hong Kong<\/p>\n\n\n\n

09\/1976\u201308\/1977            Postdoctoral Fellow, Colorado State University, USA (Professor L. S. Hegedus)<\/p>\n\n\n\n

AWARDS\/HONOURS<\/u><\/strong><\/p>\n\n\n\n

\u2022 The Order of the Sacred Treasure, Gold Rays with Neck Ribbon 2021(Emperor of Japan)<\/p>\n\n\n\n

\u2022 Yamada\u2013Koga Prize 2016 (Japan Research Foundation for Optically Active Compounds)<\/p>\n\n\n\n

\u2022 Foundation Lectureship Award 2013 in Organic Chemistry, 2013 (Federation of Asian Chemical Societies)<\/p>\n\n\n\n

\u2022 The Medal with Purple Ribbon (Shiju Hosho) 2010 (The Japanese Government)<\/p>\n\n\n\n

\u2022 Khwarizmi International Award, 2010 (IROST, Iran)<\/p>\n\n\n\n

\u2022 Author C. Cope Scholar Awards, 2008 (The American Chemical Society, USA)<\/p>\n\n\n\n

\u2022 The Ryoji Noyori Prize, 2007 (The Society of Synthetic Organic Chemistry<\/a>, Japan<\/a>)<\/p>\n\n\n\n

\u2022 Molecular Chirality Award, 2005 (Japan)<\/p>\n\n\n\n

\u2022 Thomson Scientific Research Front Award, 2004 (Japan)<\/p>\n\n\n\n

\u2022 The Chemical Society of Japan Award, 2003 (The Chemical Society of Japan)<\/p>\n\n\n\n

\u2022 IBM Japan Science Prize, 1991 (Japan)<\/p>\n\n\n\n

\u2022 The Society of Synthetic Organic Chemistry, Japan, Award for Young Scientists, 1983 (Japan)<\/p>\n\n\n\n

\u2022 Negishi\u2013Brown Lectures, 2014 (Purdue University, USA)<\/p>\n\n\n\n

\u2022 Robert Robinson Lectureship, 2014 (Oxford University, UK)<\/p>\n\n\n\n

\u2022 Boehringer-Ingelheim Lectureship, 2013 (Boston College, USA)<\/p>\n\n\n\n

\u2022 Aldrich Lecturer, 2012 (The Scripps Research Institute)<\/p>\n\n\n\n

\u2022 The Pfizer Lectureship, 2011 (Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Canada)<\/p>\n\n\n\n

\u2022 AstraZeneca Lecture in Memory of Nils L\u00f6fgren, 2011 (Stockholm University, Sweden)<\/p>\n\n\n\n

\u2022 The Pfizer & Sigma Aldrich Lecture, 2008 (University of Bristol, UK)<\/p>\n\n\n\n

\u2022 Herbert C. Brown Lecturers, 2007 (Purdue University, USA)<\/p>\n\n\n\n

\u2022 Boehringer Ingelheim Lecturer, 2007 (Universit\u00e9 de Montr\u00e9al, Canada)<\/p>\n\n\n\n

\u2022 2007 UC Irvine-Pfizer Symposium on Organic Synthesis, 2007 (University of California, Irvine, USA)<\/p>\n\n\n\n

\u2022 Morris S. Kharasch Visiting Professor, 2006 (The University of Chicago, USA)<\/p>\n\n\n\n

\u2022 The 20th Annual W. S. Johnson Symposium in Organic Chemistry, 2005 (Stanford University, USA)<\/p>\n\n\n\n

\u2022 2004 Pfizer Symposium, 2004 (Harvard University, USA)<\/p>\n\n\n\n

\u2022 Oppolzer Lectures 2003, 2003 (Universit\u00e9 de Gen\u00e8ve, Switzerland)<\/p>\n\n\n\n

\u2022 The Second Annual Merck\/Caltech Symposium on Organic Synthesis, 2003 (Caltech, USA)<\/p>\n\n\n\n

\u2022 Novartis Chemistry Lectureship 2001\/2002 (Novartis, Switzerland)<\/p>\n\n\n\n

\u2022 2000-2001 Novartis Lecturer in Organic Chemistry, 2001 (Massachusetts Institute of Technology, USA)<\/p>\n\n\n\n

EDITORIAL BOARD MEMBER<\/u><\/strong><\/p>\n\n\n\n

\u2022 Tetrahedron Asymmetry<\/em>: 1990\u20132017. Editor & Executive Board Member<\/p>\n\n\n\n

\u2022 Bull. Chem. Soc. Jpn.<\/em>: 2012\u2013present. Advisory Board<\/p>\n\n\n\n

RESEARCH INTERESTS<\/u><\/strong><\/p>\n\n\n\n

\u2022 Organic Chemistry: Selective Organic Synthesis Catalyzed by Transition Metal Complexes, Asymmetric Catalysis<\/p>\n\n\n\n

\u2022 Organometallic Chemistry: Mechanism of Catalytic Reactions<\/p>\n\n\n\n

PUBLICATIONS<\/u><\/strong><\/strong><\/p>\n\n\n\n

Selected Original papers in 2015-2024 (out of 611 publications, 55,050 total citations, H index = 132, Research.com) <\/strong>https:\/\/research.com\/scientists-rankings\/chemistry<\/p>\n\n\n\n

1.    Desymmetrization of 2-(1,5-Dialkoxypent-3-yl)phenyl Grignard Reagents by Rhodium-Catalyzed Asymmetric 1,4-Shift\/\u03b2-Alkoxy Elimination. Tsai, Y.-H.; Chen, Y.-H.; Sun, T.-W.; Chen, S.-W.; Wu, H.-L.; Hayashi, T. ACS Catalysis<\/em> 2024<\/strong>, 14<\/em>, 9505\u20139510. DOI: org\/10.1021\/acscatal.4c02879<\/p>\n\n\n\n

2.    Ligand-Controlled Regiodivergent Arylation of Aryl(alkyl)alkynes and Asymmetric Synthesis of Axially Chiral 9-Alkylidene-9,10-dihydroanthracenes. Sun, C.; Qi, T.; Rahman, F.-U.; Hayashi, T.; Ming, J. Nature Commun<\/em>. 2024<\/strong>, 15<\/em>, 9307. DOI: org\/10.1038\/s41467-024-53767-4<\/p>\n\n\n\n

3.    Carbon-Silicon-Switch Effect in Enantioselective Construction of Silicon-Stereogenic Center from Silacyclohexadienones. Yan, Y.; Wei, Q.; Su, Z.; Hang, N.-N.; Hayashi, T.; Ming, J.  Nature Commun<\/em>. 2024<\/strong>, 15<\/em>, 9915. DOI: org\/10.1038\/s41467-024-54241-x<\/p>\n\n\n\n

4.    Secondary Phosphine Sulfide-Enabled Iridium-Catalyzed Asymmetric Allylic Substitution. Wu, Z.-H.; Wang, H.-Y.; Yang, H.-L.; Wei, L.-H.; Hayashi, H.; Duan W.-L. Angew. Chem. Int. Ed.<\/em> 2022<\/strong>, 61<\/em>, DOI: org\/10.1002\/anie.202213904<\/a><\/p>\n\n\n\n

5.    Chiral Diene Ligands in Asymmetric Catalysis. Huang, Y.; Hayashi, T. Chem. Rev<\/em>. 2022<\/strong>, 122<\/em>, 14346\u201314404.<\/p>\n\n\n\n

6.    Asymmetric Synthesis of Fluorinated Allenes by Rhodium-Catalyzed Enantioselective Alkylation\/Defluorination of Propargyl Difluorides with Alkylzincs. Ng. J. S.; Hayashi, T. Angew. Chem. Int. Ed.<\/em> 2021<\/strong>, 60<\/em>, 20771\u201320775.<\/p>\n\n\n\n

7.    Asymmetric Synthesis of Alkylzincs by Rhodium-Catalyzed Enantioselective Arylative Cyclization of 1,6-Enynes with Arylzincs. Chen, J.; Hayashi, T. Angew. Chem. Int. Ed.<\/em> 2020<\/strong>, 59<\/em>, 18510\u201318514.<\/p>\n\n\n\n

8.    Synthesis of Arylacetaldehydes by Iridium-Catalyzed Arylation of Vinylene Carbonate with Arylboronic Acids. Wang, Z.; Xue, F.; Hayashi, T. Angew. Chem. Int. Ed.<\/em> 2019<\/strong>, 58<\/em>, 11054\u201311057.<\/p>\n\n\n\n

9.    Enantioselective Synthesis of 3,3\u2019-Diaryl-SPINOLS by Rh-Catalyzed Asymmetric Arylation\u2013BF3<\/sub>-Promoted Spirocyclization Reactions. Yin, L.; Xing, J.; Wang, Y.; Shen, Y.; Lu, T.; Hayashi, T. Dou, X. Angew. Chem. Int. Ed.<\/em> 2019<\/strong>, 58<\/em>, 2474\u20132478.<\/p>\n\n\n\n

10.   Addition of arylstannanes to alkynes giving ortho<\/em>-alkenylarylstannanes catalysed cooperatively by a rhodium complex and zinc chloride. Ming, J.; Shi, Q.; Hayashi, T. Chem. Sci.<\/em> 2018<\/strong>, 9<\/em>, 7700\u20137704.<\/p>\n\n\n\n

11.   Asymmetric Synthesis of Axially Chiral 2-Aminobiaryls by Rhodium-Catalyzed Benzannulation of 1-Arylalkynes with 2-(Cyanomethyl)phenylboronates. Xue, F.; Hayashi, T. Angew. Chem. Int. Ed.<\/em> 2018<\/strong>, 57<\/em>, 10368\u201310372.<\/p>\n\n\n\n

12.   Rhodium-Catalyzed Enantioposition Selective Hydroarylation of Divinylphosphine Oxides with Arylboroxines. Wang, Z.; Hayashi, T. Angew. Chem. Int. Ed.<\/em> 2018<\/strong>, 57<\/em>, 1702\u20131706.<\/p>\n\n\n\n

13.   Dynamic Kinetic Resolution in Rhodium-Catalyzed Asymmetric Arylation of Phospholene Oxides. Lim, K.M.-H.; Hayashi, T. J. Am. Chem. Soc<\/em>. 2017<\/strong>, 139<\/em>, 8122\u20138125.<\/p>\n\n\n\n

14.   Rhodium-Catalyzed Asymmetric Arylation\/Defluorination of 1-(Trifluoromethyl)alkenes Forming Enantioenriched 1,1-Difluoroalkenes. Huang, Y.; Hayashi, T. J. Am. Chem. Soc<\/em>. 2016<\/strong>, 138<\/em>, 12340\u201312343.<\/p>\n\n\n\n

15.   Base Free Conditions for Rhodium-Catalyzed Asymmetric Arylation To Produce Stereochemically Labile \u03b1-Arylketones. Dou, X.; Lu, Y.; Hayashi, T. Angew. Chem. Int. Ed.<\/em> 2016<\/strong>, 55<\/em>, 6739\u20136743.<\/p>\n\n\n\n

16.   Asymmetric Conjugate Alkynylation of Cyclic \u03b1,\u03b2-Unsaturated Carbonyl Compounds with a Chiral Diene\u2013Rhodium Catalyst. Dou, X.; Huang, Y.; Hayashi, T. Angew. Chem. Int. Ed.<\/em> 2016<\/strong>, 55<\/em>, 1133\u20131137.<\/p>\n\n\n\n

17.   Asymmetric Synthesis of Triarylmethanes by Rhodium-Catalyzed Enantioselective Arylation of Diarylmethylamines with Arylboroxines.  Huang, Y.; Hayashi, T. J. Am. Chem. Soc<\/em>. 2015<\/strong>, 137<\/em>, 7556\u20137559. <\/p>\n\n\n\n

18.   Rhodium-Catalyzed Asymmetric Arylation of Allyl Sulfones under the Conditions of Isomerization into Alkenyl Sulfones. Lim, K.M.-H.; Hayashi, T. J. Am. Chem. Soc<\/em>. 2015<\/strong>, 137<\/em>, 3201\u20133204. <\/p>\n\n\n\n

19.   Nickel-Catalyzed Three-Component Domino Reactions of Aryl Grignard Reagents, Alkynes, and Aryl Halides Producing Tetrasubstituted Alkenes. Xue, F.; Zhao, J.; Hor,T. S. A.; Hayashi, T. J. Am. Chem. Soc<\/em>. 2015<\/strong>, 137<\/em>, 3189\u20133192.  <\/p>\n\n\n\n

20.   Tandem Catalysis of Amines Using Porous Graphene Oxide. Su, C.; Tandiana, R.; Balapanuru, J.; Tang, W.; Pareek, K.; Nai, C. T.; Hayashi, T.; Loh, K. P. J. Am. Chem. Soc<\/em>. 2015<\/strong>, 137<\/em>, 685\u2013690.<\/p>\n\n\n\n

Selected Papers with High Citation (citation numbers are those at 2024)<\/p>\n\n\n\n

1.    Rhodium-Catalyzed Asymmetric 1,4-Addition and its Related Asymmetric Reactions. Hayashi, T; Yamasaki, K. Chem. Rev<\/em>. 2003<\/strong>, 103<\/em>, 2829\u20132844. [cited 1861]<\/strong><\/p>\n\n\n\n

2.    Catalytic Asymmetric Aldol Reaction: Reaction of Aldehydes with Isocyanoacetate Catalyzed by a Chiral Ferrocenylphosphine-Gold(I) Complex. Ito, Y.; Sawamura, M.; Hayashi, T. J. Am. Chem. Soc<\/em>. 1986<\/strong>, 108<\/em>, 6405\u20136406. [cited 970]<\/strong><\/p>\n\n\n\n

3.    Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl- and Alkenylboronic Acids to Enones. Takaya, Y.; Ogasawara, M.; Hayashi, T.; Sakai, M.; Miyaura, N. J. Am. Chem. Soc.<\/em> 1998<\/strong>, 120<\/em>, 5579\u20135580. [cited 862]<\/strong><\/p>\n\n\n\n

4.    Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II): An Effective Catalyst for Cross-Coupling of Secondary and Primary Alkyl Grignard and Alkylzinc Reagents with Organic Halides. Hayashi, T.; Konishi, M.; Kobori, Y.; Kumada, M.; Higuchi, T.; Hirotsu, K. J. Am. Chem. Soc<\/em>. 1984<\/strong>, 106<\/em>, 158\u2013163. [cited 743]<\/strong><\/p>\n\n\n\n

5.    Catalytic Cycle of Rhodium-Catalyzed Asymmetric 1,4-Addition of Organoboronic Acids.  Arylrhodium, Oxa-\u03c0-allylrhodium, and Hydroxorhodium Intermediates. Hayashi, T.; Takahashi, M.; Takaya, Y.; Ogasawara. M. J. Am. Chem. Soc.<\/em> 2002<\/strong>, 124<\/em>, 5052\u20135058. [cited 734]<\/strong><\/p>\n\n\n\n

6.    Asymmetric Synthesis Catalyzed by Chiral Ferrocenylphosphine-Transition Metal Complexes.  I.  Preparation of Chiral Ferrocenylphosphines. Hayashi, T.; Mise, T.; Fukushima, M.; Kagotani, M.; Nagashima, N.; Hamada, Y.; Matsumoto, A.; Kawakami, S.; Konishi, M.; Yamamoto, K.; Kumada, M. Bull. Chem. Soc. Jpn<\/em>. 1980<\/strong>, 53<\/em>, 1138\u20131151. [cited 607]<\/strong> <\/p>\n\n\n\n

7.    A Chiral Chelating Diene as a New Type of Chiral Ligand for Transition Metal Catalysts:  Its Preparation and Use for the Rhodium-Catalyzed Asymmetric 1,4-Addition. Hayashi, T.; Ueyama, K.; Tokunaga, N.; Yoshida, K. J. Am. Chem. Soc<\/em>. 2003<\/strong>, 125<\/em>, 11508\u201311509. [cited 579]<\/strong><\/p>\n\n\n\n

8.    Chiral Monodentate Phosphine Ligand MOP for Transition-Metal-Catalyzed Asymmetric Reactions. Hayashi, T. Acc. Chem. Res.<\/em> 2000<\/strong>, 33<\/em>, 354-362. [cited 589]<\/strong><\/p>\n\n\n\n

9.    C<\/em>2<\/sub>-Symmetric Bicyclo[2.2.2]octadienes as Chiral Ligands: Their High Performance in Rhodium-Catalyzed Asymmetric Arylation of N<\/em>-Tosylarylimines. Tokunaga, N.; Otomaru, Y.; Okamoto, K.; Ueyama, K.; Shintani, R.; Hayashi, T. J. Am. Chem. Soc<\/em>. 2004<\/strong>, 126<\/em>, 13584\u201313585. [cited 533]<\/strong><\/p>\n\n\n\n

10.   tert-<\/em>Butoxide-Mediated Arylation of Benzene with Aryl Halides in the Presence of a Catalytic 1,10-Phenanthroline Derivative<\/a>. Shirakawa, E.; Itoh, K.; Higashino, T.; Hayashi, T.<\/a> J. Am. Chem. Soc. <\/em>2010<\/strong>, 132, <\/em>15537<\/a>-15539.<\/em> [cited 485]<\/strong><\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

Title: Recent Advances in Rhodium-Catalyzed Asymmetric Arylation<\/p>","protected":false},"author":1,"featured_media":309,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-202","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-plenary-speakers"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/posts\/202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/comments?post=202"}],"version-history":[{"count":3,"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/posts\/202\/revisions"}],"predecessor-version":[{"id":308,"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/posts\/202\/revisions\/308"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/media\/309"}],"wp:attachment":[{"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/media?parent=202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/categories?post=202"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/orgchemtr6.org\/tr\/wp-json\/wp\/v2\/tags?post=202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}